http://www.robholland.com/Nursing/Drug_Guide/data/monographframes/A009.html Web13. máj 2013 · We extracted data on serum phenytoin concentrations, albumin, triglycerides, urea, total bilirubin and creatinine concentrations and data on coadministration of valproic acid or carbamazepine in 186 children. Using nonlinear mixed effects modeling the effects of covariates on the unbound phenytoin fraction were investigated.
Phenytoin: A Guide to Therapeutic Drug Monitoring - SAGE Journals
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5 (4 Hydroxyphenyl) 5 Phenylhydantoin - an overview - ScienceDirect
WebPhenytoin is highly protein-bound (90%), mostly to albumin. Ten percent of the phenytoin circulates in the free, unbound form. Free phenytoin is the active form of the drug, available to cross biologic membranes and bind to receptors. Increased free phenytoin produces an enhanced pharmacologic effect. At the same time, the free fraction is more ... Web17. feb 2024 · The rate of intravenous phenytoin administration should not exceed 50 mg/minute in adults and 1 to 3 mg/kg/minute (or 50 mg/minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias. Careful cardiac monitoring is needed during and after administering intravenous phenytoin. WebBe sure to mention any of the following: ephedrine, epinephrine, phenylephrine, phenylpropanolamine, or pseudoephedrine. Many other medications may also interact with theophylline, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. spooling technique