Cytoglobin function
WebJun 15, 2024 · Toxicology Letters December 15, 2008. Cytoglobin (Cygb) is a recently discovered hexacoordinate globin protein with a yet undefined function. It was found to be up-regulated in toxin-induced liver ... Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during oxidative stress. See more Cytoglobin is the protein product of CYGB, a human and mammalian gene. Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 … See more CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. See more • cytoglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells". The Journal of … See more
Cytoglobin function
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WebCytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O 2 reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood. Here, the X-ray crystal structure of wild type … WebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to …
WebDec 28, 2024 · Abstract Cytoglobin (Cygb) was discovered as a novel type of globin that is expressed in mammals; however, its functions remain uncertain. While Cygb protects against oxidant stress, the basis for this is unclear, and the effect of Cygb on superoxide metabolism is unknown. WebOct 13, 2024 · Cytoglobin has potent superoxide dismutase function. TGF-beta1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
WebOct 13, 2024 · Cygb is an oxygen-responsive tissue hemoglobin expressed in distinct regions of thenormoxic and hypoxic brain and may play a key role in the response of the brain to ahypoxic insult. differential expression of cytoglobin argues against a general respiratory function of this molecule, but rather indicates a connective tissue-specific … WebApr 10, 2024 · Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates...
WebMay 16, 2024 · Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress ( Trent and Hargrove, 2002 ). Cloning and Expression
WebDec 7, 2016 · Cytoglobin (Cygb), identified as a new globin family member protein, is expressed in various tissues. Although its interaction with oxygen and nitric oxide indicates the potential role in antioxidant pathways, the exact role remains unclear. ... Cygb could serve an O 2 scavenging and supplying function, and could contribute to the ... inappropriate things in kids showsWebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to limit the inactivation of peroxiredoxin 2 and alter Hyper7 signal was still surprising to us because the heme peroxidase activity of cytoglobin is several folds slower than peroxiredoxin 29 inappropriate therapy vision lossWebFeb 14, 2024 · Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather than constrained to penta coordination, cytoglobin's heme iron may … inchelinWebJul 9, 2011 · Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. incheiere email formalWebOct 3, 2024 · Cytoglobin is a highly conserved redox sensor heme protein with unknown physiological function. Unexpectedly, genetic deletion of zebrafish cytoglobin ( cygb2 ) causes cardiac and... incheiere exportWebGlobins are ubiquitous heme-binding a-helical proteins whose function is principally thought to regulate oxygen homoeostasis [1, 2]. ... (Mb), cytoglobin (Cygb), and neuroglobin (Ngb). Hb is located in erythrocytes, which transport O 2 from the lungs to tissues through the circulatory system and CO 2 in the opposite direction. inappropriate thesaurusWebMost known globins fulfill respiratory functions, supplying the cell with adequate amounts of O 2 for aerobic energy production via the respiratory chain in the mitochondria [5–7]. ... [16–18] and is now officially named cytoglobin (Cygb), based on its widespread expression in many mammalian tissues and organs. incheiere powerpoint