WebMoreover, CIP2A protein expression was induced in breast cancer mouse models presenting mammary gland-specific depletion of p53 and either BRCA1 or BRCA2. Functionally, CIP2A depletion was shown to inhibit the expression of its target protein c-Myc. Loss of CIP2A also inhibited anchorage-independent growth in breast cancer cells. WebOct 21, 2010 · Furthermore, CIP2A has prognostic significance in certain subgroups of gastric cancer . The CIP2A protein also promoted growth of breast cancer xenografts, and expression of the transcript was found to correlate with the expression of proliferation markers and p53 mutations, and with lymph node positivity in clinical breast cancer …
CIP2A is Overexpressed in Non-Small Cell Lung Cancer and
WebMay 1, 2024 · KIAA1524 is the gene encoding the human cancerous inhibitor of PP2A (CIP2A) protein which is regarded as a novel target for cancer therapy. It is overexpressed in 65%–90% of tissues in almost ... Web1 day ago · Lång’s team has developed an algorithm based on Artificial Intelligence (AI) that utilizes a low-cost, handheld ultrasound probe connected to a mobile phone to detect breast cancer tumors. In ... hikvision delete specific recording
Prognostic significance of CIP2A expression in solid tumors: A …
WebFeb 24, 2024 · According to numerous studies, the high expression of CIP2A/p90 in some cancers, such as cutaneous melanoma, breast cancer, colon cancer, cervical cancer, prostate cancer, and oral cancer, is associated with pathologic high-grade tumor and the progression of disease ( Côme et al., 2009; Vaarala et al., 2010; Böckelman et al., … WebSep 15, 2010 · Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein inhibiting proteolytic degradation of c-MYC. In this study, we investigated the clinical relevance of CIP2A in NSCLC. Materials and Methods We analyzed CIP2A mRNA expression in 29 NSCLC tissues using quantitative reverse transcription polymerase … WebAug 15, 2024 · Specifically, we demonstrate by using both chemical and transgenic tumor models that CIP2A is essential for the initiation of mouse BLBC tumors, but not for the initiation of skin, ovarian, lung or stomach … small wood burner with back boiler