WebOct 15, 2006 · Botrocetin (bt)-facilitated binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein (GP) Ib-IX-V complex on platelets in suspension initiates a signaling cascade that causes alphaIIbbeta3 activation and platelet aggregation. WebThe venom botrocetin binds to the VWF A1 domain, potentiating its interaction with the GPIbα chain [ 11 ]. Upon vascular damage or atherosclerotic plaque rupture, collagen-bound VWF, in a shear-dependent way, initiates thrombus formation through a fast onset of GPIb-V-IX-binding and platelet adhesion [ 12, 13, 14 ].
Botrocetin - an overview ScienceDirect Topics
WebNoun [ edit] botrocetin ( uncountable ) ( biochemistry) A coagglutinin, present in snake venom, that causes platelet aggregation This page was last edited on 28 July 2016, at 15:44. Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. WebBotrocetin From: Transfusion Medicine and Hemostasis (Third Edition), 2024 Download as PDF About this page Inherited Disorders of Platelet Function Alan T. Nurden, Paquita Nurden, in Platelets (Second Edition), 2007 1 Platelet Function Abnormalities. crony capitalists
Bothrops - an overview ScienceDirect Topics
WebBotrocetin, originally called venom coagglutinin, is a Bothrops factor that causes aggregation of blood platelets in the presence of the von Willebrand component of the factor VIII … To show that botrocetin cannot form stable adhesions with platelets in the absence of the A1 domain, we evaluated platelet binding to surface-immobilized botrocetin under static conditions. After an incubation period of 10 min, few platelets remained attached upon the application of flow (Fig. 4a). By contrast, >50% … See more To shed light on the ability of botrocetin to 'activate' vWF such that it enhances its interaction with platelets, we first determined the crystal structure of the mouse A1–botrocetin … See more To determine the structure of the human ternary complex, we expressed the vWF-A1 binding domain of GPIbα using recombinant … See more The rigid-body movement of botrocetin in the ternary complex involves repacking of side chains at the A1-botrocetin interface (Fig. 3a,b). Two out of five salt bridges (using a distance cutoff of 3.5 Å) that occur within this … See more Comparison of the human ternary complex with the human A1–botrocetin binary complex reveals a marked rigid-body slide and rotation of … See more WebNov 5, 2024 · Botrocetin inhibited platelet aggregation and thrombus formation in VWF-deficient mice. Conclusion: Integrin αIIbβ3 is the alternative receptor that mediates VWF-dependent, GPIb-independent... buffstreams epl